ArticleGriffin WS, Woodward DJ, Chanda R.
Brain Res Bull. 1978 Jul-Aug;3(4):365-7.
DNA synthetic ability of neonatal rat cerebellum was studied in two stressful conditions (cooling and excessive handling) which may be inadvertently imposed during the course of certain experiments. A rate study of the ability of animals handled excessively for 10 min to incorporate 14C-thymidine into the DNA tissue fraction (DNAF) from the acid soluble tissue fraction (ASF) of the cerebellum revealed a decreased DNA synthetic ability which lasted for 1 hr. Animals with very low core temperatures incorporated little 14C into the DNAF from the ASF 2 hr after an IP injection of 14C-thymidine. There was a proportional decrease in the ability to synthesize DNA as core temperature decreased.